Medical Research Insights - MRIs

Medical Research Insights - MRIs Curated Medical Research Insights (MRIs) [daily]

Scientists have successfully identified a gene key to colon cancer and discovered one possible way the environment aroun...
10/21/2022

Scientists have successfully identified a gene key to colon cancer and discovered one possible way the environment around a colon cancer tumor can trigger malignant growth; via

Genetic evidence shows that targeting PDZK1IP1 inhibits tumors....

As pharma companies shift from developing drugs that serve large populations to specialty drugs, targeting the right pat...
10/05/2022

As pharma companies shift from developing drugs that serve large populations to specialty drugs, targeting the right patients becomes a key driver of success. Analyzing patient-level real-world data is essential for the successful launch and management of new products.

By Carolyn Zele, Advisor, Solution Consulting, MMIT, and Lance Wolkenbrod, Senior Director, Commercial Solutions, Panalgo | Despite investing heavily in the right data and analytics to inform their commercial strategy, many pharma companies do no...

As CAR T-cell products become more important in the fight against diseases, the FDA is making new recommendations for CA...
10/05/2022

As CAR T-cell products become more important in the fight against diseases, the FDA is making new recommendations for CAR T-cell developers. Our own David Perez-Caballero, Ph.D., talks to Genetic Engineering & Biotechnology News about the new guidance.

A CRO summarizes the FDA’s recommendations for developers and highlights issues that have been raised in public comments....

Cancer cells will stop at nothing to grow—right down to deleting sections of their DNA that contain growth suppression g...
09/30/2022

Cancer cells will stop at nothing to grow—right down to deleting sections of their DNA that contain growth suppression genes. | Pinning down backup genes along with the metabolic pathways they’re regulating, has historically required tedious screenings that gave limited information about how different genes interact. Now, a team of researchers has used machine learning to streamline the process and add context that could make precision medicines more precise.

Cancer cells will stop at nothing to grow—right down to deleting sections of their DNA that contain growth suppression genes. | Pinning down backup genes along with the metabolic pathways they’re regulating, has historically required tedious scree...

Researchers from King’s College London and The Institute of Cancer Research, London, have identified immune cell types t...
09/30/2022

Researchers from King’s College London and The Institute of Cancer Research, London, have identified immune cell types that could be targeted to develop specific immunotherapies for patients whose cancer failed to respond to chemotherapy.

Several cell types that worth investigating further were identified to understand how they interact with resistant cancer cells....

An program developed by researchers at Stanford calculated measurements more accurately than those performed by human ...
09/09/2022

An program developed by researchers at Stanford calculated measurements more accurately than those performed by human clinicians in the trial.

An artificial intelligence program developed by researchers at Stanford University was able to streamline ultrasound exams of the heart—to the point where trained cardiologists couldn’t tell whethe | An artificial intelligence program developed by...

The pandemic brought to the forefront of public awareness. Now there are huge opportunities for growth and innovatio...
09/09/2022

The pandemic brought to the forefront of public awareness. Now there are huge opportunities for growth and innovation across the industry.

Manohara B Halasiddappa...

Half of all patients are children, and — out of desperation to find a cure — more and more families are forming their ...
09/07/2022

Half of all patients are children, and — out of desperation to find a cure — more and more families are forming their own foundations to grow funds for research.

Families are forming their own businesses to find treatments for ultra-rare diseases that affect fewer than 1,000 patients, territory many drugmakers deem too risky....

Although and are hot buzz words in science today, much more work could be done in applying these techniques to biopr...
09/07/2022

Although and are hot buzz words in science today, much more work could be done in applying these techniques to bioprocessing. GEN speaks to an expert who sees 3 major benefits. Read more:

Using AI/ML-based surrogates to digitally mimic the real system leads to the reduction of resources and accelerates the process development timeline....

Researchers have found that increasing a genetic quirk can boost beta amyloid clearance, holding the potential to help p...
09/04/2022

Researchers have found that increasing a genetic quirk can boost beta amyloid clearance, holding the potential to help prevent Alzheimer’s.

Scientists have discovered a new druggable pathway that may boost beta amyloid clearance, holding the potential to be used to help prevent Alzheimer’s dementia in humans. | Scientists have discovered a new druggable pathway that may boost beta amy...

It’s the 20th year Fierce Biotech sought out the most innovative private biotechs, so now they are checking in on past h...
09/04/2022

It’s the 20th year Fierce Biotech sought out the most innovative private biotechs, so now they are checking in on past honorees.

It’s the 20th year we’ve sought out the most innovative private biotechs, which also means we've entered the second decade of checking in on our past honorees. In 2012, we profiled the biggest risk takers in biotech, narrowing our list down to 1...

FDA Commissioner Robert Califf says the industry and researchers should redouble its efforts to treat common chronic d...
09/03/2022

FDA Commissioner Robert Califf says the industry and researchers should redouble its efforts to treat common chronic diseases and addiction. Read up on his new editorial article.

FDA Commissioner Robert Califf, M.D., has often been blunt and direct when outlining his goals and aspirations for the FDA since taking the helm for the second time earlier this year. | FDA Commissioner Robert Califf says the biopharma industry a...

Great to see that ’s show, “Double Take,” will feature models from the spinal muscular atrophy ( ) community with the ...
09/03/2022

Great to see that ’s show, “Double Take,” will feature models from the spinal muscular atrophy ( ) community with the aim of increasing disability visibility! Initiatives like this are so important for promoting diversity in professional spaces, where individuals with disabilities — whether visible or invisible — must be given an equal opportunity to succeed, learn, grow, and be compensated fairly.

Roche’s Genentech is going high style next month for New York Fashion Week. The pharma is hosting its first-ever runway fashion show to raise disability visibility, featuring models from the spinal muscular atrophy (SMA) community. “Double Take” w...

Vas Narasimhan of shares his reflections on the full arc of human progress within the industry, which uncovers the e...
09/02/2022

Vas Narasimhan of shares his reflections on the full arc of human progress within the industry, which uncovers the extraordinary moment we’re in.

We’re at a turning point in the history of medicine. Science and technology are advancing at an unprecedented pace, and we have more knowledge at our fingertips than ever before....

Researchers at MIT report that Alzheimer’s disease disrupts at least one form of visual memory in mice by degrading a ne...
09/02/2022

Researchers at MIT report that Alzheimer’s disease disrupts at least one form of visual memory in mice by degrading a newly identified circuit that connects the vision processing centers of each brain hemisphere. "In a way we uncovered a fundamental biology that was not known before.”
Read on.

Disruption of the brain’s cross hemispheric connectivity circuit in Alzheimer’s mouse models is associated with specific behavioral deficits....

The group has introduced a downloadable guide, interactive quiz, and other tools to inform patients from underrepresente...
08/31/2022

The group has introduced a downloadable guide, interactive quiz, and other tools to inform patients from underrepresented communities about trial participation.

The group has introduced a downloadable guide, interactive quiz, and other tools to inform patients from underrepresented communities about trial participation....

Machine learning is expected to become common in drug production if industry, the tech sector, and regulators put in the...
08/31/2022

Machine learning is expected to become common in drug production if industry, the tech sector, and regulators put in the groundwork.

With the effective incorporation of inter-disciplinary fields, machine learning might be commonly used in the biopharma industry in the upcoming 5–10 years....

Minority patients are not participating in clinical trials because they do not trust the medical community, and FDA has ...
08/28/2022

Minority patients are not participating in clinical trials because they do not trust the medical community, and FDA has noted the lack of diversity and inclusion of patients in clinical trials. In this interview, Patrice Matchaba, MD, President of Novartis US Foundation, created The Beacon of Hope, the first Clinical Trial Center of Excellence focusing on building bridges between clinical trials and minority communities, will discuss how the biopharmaceutical industry can regain the trust of minorities.

In this interview, Patrice Matchaba, MD, President of Novartis US Foundation discusses how the biopharmaceutical industry can regain the trust of minorities....

"We’re at a turning point in the history of medicine. Science and technology are advancing at an unprecedented pace, and...
08/28/2022

"We’re at a turning point in the history of medicine. Science and technology are advancing at an unprecedented pace, and we have more knowledge at our fingertips than ever before." Vas Narasimhan, CEO of Novartis, shares his reflections on the history of the biopharmaceutical industry, as well as thoughts on how the latest scientific breakthroughs could lead to real progress we can feel in our everyday lives.

We’re at a turning point in the history of medicine. Science and technology are advancing at an unprecedented pace, and we have more knowledge at our fingertips than ever before....

Biotechs have yet to discover a therapeutic key for the frustrating disease lock that is nonalcoholic steatohepatitis (N...
08/19/2022

Biotechs have yet to discover a therapeutic key for the frustrating disease lock that is nonalcoholic steatohepatitis (NASH). Scientists from the University of Michigan have further uncovered the impact of a hormone secreted by fat cells in mice with NASH. When the hormone was knocked out in mice, there was an increase in tumor growth compared to the control.

Biotechs have yet to discover a therapeutic key for the frustrating disease lock that is nonalcoholic steatohepatitis (NASH). | Scientists from the University of Michigan have further uncovered the impact of a hormone secreted by fat cells in mice...

Why does thinking hard make us tired? Results suggest that monitoring brain metabolites could aid detection of mental fa...
08/19/2022

Why does thinking hard make us tired? Results suggest that monitoring brain metabolites could aid detection of mental fatigue, and potentially inform on how to adjust work agendas to avoid burnout. Note: the paper advises people to avoid making important decisions when they’re tired.

Results suggest that monitoring brain metabolites could aid detection of mental fatigue, and potentially inform on how to adjust work agendas to avoid burnout....

Researchers are initiating a feasibility study investigating the effects of terazosin in patients with motor neuron dise...
08/17/2022

Researchers are initiating a feasibility study investigating the effects of terazosin in patients with motor neuron disease. Repurposing terazosin has the potential to increase the limited therapeutic options across all forms of , irrespective of disease cause.

Researchers are now initiating a feasibility study investigating the effects of terazosin in patients with motor neuron disease....

For the first time in India, researchers have successfully 3D-printed an artificial cornea and transplanted it into a ra...
08/17/2022

For the first time in India, researchers have successfully 3D-printed an artificial cornea and transplanted it into a rabbit eye. This made-in-India product could offer an affordable solution to corneal .

A made-in-India product by an Indian clinician-scientist team that could offer an affordable solution to corneal blindness. Can be sight-saving for ar.....

A new study sheds light on a possible mechanism to enhance the efficacy of approaches for alpha-1 antitrypsin deficien...
08/13/2022

A new study sheds light on a possible mechanism to enhance the efficacy of approaches for alpha-1 antitrypsin deficiency.

A new study sheds light on a possible mechanism to enhance the efficacy of gene therapy approaches for alpha-1 antitrypsin deficiency....

Researchers have developed a method that could be used to ensure long-lasting medical device implants do not trigger an...
08/13/2022

Researchers have developed a method that could be used to ensure long-lasting medical device implants do not trigger an immune response, allowing them to keep working without being rejected by the body.

Researchers at MIT have developed a method that could be used to ensure long-lasting medical device implants do not trigger an immune response. | Researchers at MIT have developed a method that could be used to ensure long-lasting diabetes implant...

Did you listen to this week's "The Top Line?" They explore why many early are now throwing in the towel and how pip...
08/12/2022

Did you listen to this week's "The Top Line?" They explore why many early are now throwing in the towel and how pipelines have changed, even the stuff companies are less keen to talk about.

It's earnings season—a time when publicly traded pharmas and biotechs tell their investors how they've performed over the previous quarter. | This week on "The Top Line," we explore why many early pandemic therapeutics are now throwing in the towe...

This experiment has been called "stunning." Researchers have restored circulation and cellular activity in the vital o...
08/12/2022

This experiment has been called "stunning." Researchers have restored circulation and cellular activity in the vital organs of pigs, such as the heart and brain, one hour after the animals died.

Scientists warn that the findings aren’t yet clinically relevant but say the research raises ethical questions about the definition of death....

Because the gut microbiome affects various aspects of human health such as metabolism and immunity over time, scientists...
08/10/2022

Because the gut microbiome affects various aspects of human health such as metabolism and immunity over time, scientists have been trying to plant engineered bacteria to treat chronic diseases. Now scientists at the University of California, San Diego, have found that native E. coli could be genetically modified to treat chronic disease in the host.

Because the gut microbiome affects various aspects of human health such as metabolism and immunity over time, scientists have been trying to plant engineered bacteria to treat chronic diseases. | Past research has faced challenges using bacteria c...

This is pretty cool. The life-saving potential of (VR) is now on full display, as physicians in Brazil and the U.K. re...
08/10/2022

This is pretty cool. The life-saving potential of (VR) is now on full display, as physicians in Brazil and the U.K. reported this week the success of a VR-guided to separate twins who were joined at the skull.

In just the last few years, virtual reality technology has morphed from a science-fiction pipe dream to a widely used tool in gaming, workforce training and, increasingly, healthcare. | The life-saving potential of VR is now on full display, as ph...

Achieving the goal of for all requires continued study of what makes humans different. But if has shown one thing, i...
08/05/2022

Achieving the goal of for all requires continued study of what makes humans different. But if has shown one thing, it is that what separates us is much less than what joins us together.

Achieving the goal of precision medicine for all requires continued study of what makes humans different. But if diversity research has shown one thing, it is that what separates us is much less than what joins us together....

Address

New London, CT

Website

Alerts

Be the first to know and let us send you an email when Medical Research Insights - MRIs posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Shortcuts

Share

Category